Elucidating the mechanism of cellular uptake and removal of protein love chemistry dating site

Our estimates of these sizes compare well with experimental data.

We also study the sensitivity of the obtained results on coat parameters to identify factors which significantly affect the internalization kinetics.

(Some titles may also be available free of charge in our Open Access Theses and Dissertations Series, so please check there first.) Access to abstracts is unrestricted.In this paper we study cellular uptake of viruses and NPs with a focus on coat assembly.We characterize the internalization process by the mean time between the binding of a particle to the membrane and its entry into the cell.The internalization of these nano-objects is controlled by the assembly of a clathrin-containing protein coat on the cytoplasmic side of the plasma membrane, which drives the invagination of the membrane and the formation of a cargo-containing endocytic vesicle.Current theoretical models of receptor-mediated endocytosis of viruses and NPs do not explicitly take coat assembly into consideration.

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